The 2021 Regional Quiz Bowl Tournaments were presented via Zoom with all teams competing remotely. 38 teams competed over a four-week period in February and March to advance to the March State Finals also presented via Zoom. Shown below are the rankings of the advancing teams from each Regional:
West Regional1 - Thomas Jefferson Classical HS2 - Providence HS3 - Myers Park HS4 - Atkins HS 1 - The Academy at Lincoln MS2 - Metrolina Regional Scholars Academy3 - Brown Summit MS East Regional1 - NC School of Science and Mathematics2 - The Early College at Guilford3t - Northwest Guilford HS3t - Jordan-Matthews HS 1 - Smith MS2 - Ligon MS3 - R Max Abbott MS
