The 2021 Regional Quiz Bowl Tournaments were presented via Zoom with all teams competing remotely. 38 teams competed over a four-week period in February and March to advance to the March State Finals also presented via Zoom. Shown below are the rankings of the advancing teams from each Regional:

West Regional
1 - Thomas Jefferson Classical HS
2 - Providence HS
3 - Myers Park HS
4 - Atkins HS
 
1 - The Academy at Lincoln MS
2 - Metrolina Regional Scholars Academy
3 - Brown Summit MS
 
 
 
 
 
East Regional
1 - NC School of Science and Mathematics
2 - The Early College at Guilford
3t - Northwest Guilford HS
3t - Jordan-Matthews HS
 
1 - Smith MS
2 - Ligon MS
3 - R Max Abbott MS